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Prevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children

Arik Alper1, Steven Hardee, Danilo Rojas-Velasquez

  • 1*Department of Pediatrics, Division of Pediatric Gastroenterology †Department of Pathology, Yale University School of Medicine, New Haven, CT.

Journal of Pediatric Gastroenterology and Nutrition
|August 8, 2015
PubMed

Insights

Duodenitis affects 12.7% of children undergoing endoscopy, with celiac disease and inflammatory bowel disease being common causes. Gastritis often co-occurs, and endoscopic findings may not align with histology in pediatric duodenitis.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Pathology

Background:

  • Duodenitis is understudied in children compared to gastritis and esophagitis.
  • Limited literature exists on the prevalence and characteristics of duodenitis in pediatric populations.

Purpose of the Study:

  • To determine the prevalence of duodenitis in children.
  • To investigate the etiology, clinical presentation, endoscopic findings, and pathological features of duodenitis in a large pediatric cohort.

Main Methods:

  • Retrospective review of upper endoscopy pathology reports over 5 years.
  • Confirmation of duodenitis diagnosis via biopsy review.
  • Collection of demographic, clinical, endoscopic, and histological data, including associated gastritis and esophagitis.

Main Results:

  • Duodenitis was diagnosed in 12.7% of 2772 children undergoing endoscopy.
  • Common indications included abdominal pain, diarrhea, and positive celiac serology.
  • Celiac disease (32%) and Crohn disease (13%) were leading causes; Helicobacter pylori infection was found in 6%.

Conclusions:

  • Duodenitis prevalence is 12.7% in pediatric endoscopy patients.
  • Celiac disease and inflammatory bowel disease are significant etiologies.
  • Associated gastritis is frequent, and endoscopic-pathological correlation is often poor.
Abstract

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