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Infection-associated non-Hodgkin lymphomas
1Paris Descartes University, Department of Haematology, Necker-Enfants Malades University Hospital, Institut Imagine, Paris, France; Laboratory of Molecular Mechanisms of Haematologic al Disorders and Therapeutic Implications, Institut Imagine, INSERM UMR 1163 and CNRS ERL 8254, Paris, France.
Abstract:
Non-Hodgkin lymphomas (NHLs) are malignant proliferations of lymphoid cells. Lymphoid cells proliferate in a physiological manner in response to antigen-dependent and antigen-independent signals. Some lymphotropic viruses, such as Epstein-Barr virus and human T-lymphotropic virus 1, as well as pathogens leading to chronic antigenic stimulation (such as Helicobacter pylori and hepatitis C virus), are associated with NHL. We review here some of the pathophysiological features of infection-associated NHL.
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