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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
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Long-term mortality after lower-limb amputation.

Rajiv Kumar Singh1, Guru Prasad2

  • 1Osborn Unit, Northern General Hospital, Sheffield Teaching Hospitals, Sheffield, UK rajiv.singh@sth.nhs.uk.

Prosthetics and Orthotics International
|August 9, 2015
PubMed
Summary
This summary is machine-generated.

High mortality after lower-limb amputation is linked to diabetes and not receiving a prosthesis. Prosthetic fitting may offer a survival benefit, warranting further investigation into this crucial aspect of post-amputation care.

Keywords:
Amputationdiabetes mellituslower limboutcome studiesprosthesis

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Area of Science:

  • Orthopedics
  • Vascular Surgery
  • Rehabilitation Medicine

Background:

  • Mortality rates following amputation are notably high.
  • Patient-specific factors significantly influence outcomes after amputation.
  • This study aimed to quantify mortality post-lower limb amputation and identify associated risk factors.

Purpose of the Study:

  • To determine the mortality rate in patients undergoing first-time lower limb amputation.
  • To investigate population and treatment-related factors associated with increased mortality.
  • To explore the independent impact of prosthetic limb fitting on survival rates.

Main Methods:

  • A prospective cohort study design was employed.
  • 105 patients undergoing lower limb amputation were followed for three years.
  • Data analysis included univariate and multivariable logistic regression.

Main Results:

  • A 33% mortality rate was observed within three years post-amputation (35 deaths).
  • Diabetes mellitus was significantly associated with higher mortality (OR=3.04, P=0.014).
  • Absence of prosthesis fitting independently predicted increased mortality (OR=2.60, P=0.028).

Conclusions:

  • Mortality after lower limb amputation is substantial.
  • Diabetes and lack of prosthetic fitting are independent predictors of mortality.
  • Prosthetic limb use may confer a survival benefit, independent of comorbidities.