Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

3.7K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
3.7K
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

797
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
797
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

257
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
257
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.1K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.1K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.4K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.4K
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospective analysis of adiposity metrics for complicated acute colonic diverticulitis: Should WSES Classification and visceral adiposity be integrated for predictive analyses?

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2025
Same author

Gastroenteropancreatic Neuroendocrine Tumors: Does Tumor Location Affect Prognosis?

Archives of Iranian medicine·2025
Same author

Prognostic value of the lymph node ratio in surgically treated stage III colorectal cancer patients with high numbers of harvested lymph nodes.

Acta chirurgica Belgica·2022
Same author

Prognostic significance of the preoperative lymphocyte to C-reactive protein ratio in patients with stage III colorectal cancer.

ANZ journal of surgery·2022
Same author

Effect of Helicobacter pylori infection on the first-line treatment outcomes in patients with immune thrombocytopenic purpura.

European review for medical and pharmacological sciences·2022
Same author

The clinicopathological features and survival of Castleman disease: a multicenter Turkish study.

European review for medical and pharmacological sciences·2022

Related Experiment Video

Updated: Apr 5, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

55.3K

Hyperbilirubinemia as a predictive factor in acute appendicitis.

T Eren1, E Tombalak2, I A Ozemir2

  • 1Department of General Surgery, School of Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Dr. Erkin Street, Kadikoy, 34730, Istanbul, Turkey. drtunceren@gmail.com.

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
|August 9, 2015
PubMed
Summary

Elevated bilirubin levels, particularly direct bilirubin, can predict severe appendicitis (gangrene/perforation). This finding highlights hyperbilirubinemia as a key diagnostic marker for acute appendicitis complications.

Keywords:
Acute appendicitisGangreneHyperbilirubinemiaPerforation

More Related Videos

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

181
Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

23.4K

Related Experiment Videos

Last Updated: Apr 5, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

55.3K
Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

181
Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

23.4K

Area of Science:

  • Medical research
  • Clinical diagnostics
  • Surgical pathology

Background:

  • Appendicitis is a common surgical emergency.
  • Predictive markers for appendicitis severity are crucial for timely intervention.
  • Hyperbilirubinemia's role in appendicitis has been explored but requires further clarification.

Purpose of the Study:

  • To determine if hyperbilirubinemia predicts acute, gangrenous, or perforated appendicitis.
  • To compare the predictive value of bilirubin levels with other clinical parameters.
  • To establish hyperbilirubinemia as a potential diagnostic marker for appendicitis severity.

Main Methods:

  • Retrospective analysis of 162 appendectomy cases (Sept 2013 - Sept 2014).
  • Recorded patient demographics, white blood cell count (WBC), neutrophil counts (NEU), C-reactive protein (CRP), and bilirubin levels.
  • Utilized statistical tests (Fisher's exact, Pearson's χ², ANOVA, Kruskal-Wallis) and logistic regression for analysis.

Main Results:

  • Elevated WBC, NEU, NEU%, and CRP were significant in acute and severe appendicitis.
  • Total and direct bilirubin levels were significantly higher in patients with acute and gangrenous/perforated appendicitis.
  • Multivariate analysis showed elevated CRP (14x), total bilirubin (5x), and direct bilirubin (36x) increased the risk of gangrene/perforation.

Conclusions:

  • Hyperbilirubinemia, especially elevated direct bilirubin, is a significant predictor of appendiceal gangrene/perforation.
  • Bilirubin levels offer valuable insights into appendicitis severity.
  • This study supports the use of bilirubin measurements in the clinical assessment of appendicitis.