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Related Experiment Video

Updated: Apr 5, 2026

Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing
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Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing

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Do not scratch that mole!

Mark Jelcic1, Philipp Niethammer1

  • 1Cell Biology Program, Memorial Sloan Kettering Cancer Center, 411 E 67th Street, New York, NY 10065, USA.

Trends in Immunology
|August 9, 2015
PubMed
Summary
This summary is machine-generated.

Injury can trigger melanoma development from moles by activating oncogenes. A new study in zebrafish shows that neutrophil recruitment following injury promotes the proliferation of preneoplastic melanocytes, leading to melanoma.

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Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Nevi (moles) share oncogene mutations with malignant melanoma.
  • Additional tumor-promoting events are necessary for nevi to become cancerous.

Purpose of the Study:

  • To investigate the role of injury in melanoma development.
  • To explore the mechanisms by which oncogene-driven nevi progress to melanoma.

Main Methods:

  • Utilized zebrafish model with melanocytes overexpressing an HRAS-oncogene.
  • Induced injury to observe melanoma formation.
  • Investigated the role of neutrophils in the process.

Main Results:

  • Injury was found to induce melanoma in the zebrafish model.
  • Neutrophils were recruited to the injury site.
  • Neutrophils appeared to trigger the proliferation of preneoplastic melanocytes.

Conclusions:

  • Injury can act as a tumor-promoting event in the context of oncogene-driven nevi.
  • Neutrophil recruitment following injury may be a key mechanism in melanoma initiation.
  • This study provides insights into the progression of benign nevi to malignant melanoma.