Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

5.3K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.3K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

55.3K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
55.3K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

37.3K
37.3K
pH Regulation in Cells01:28

pH Regulation in Cells

8.1K
pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
8.1K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.8K
Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

5.4K
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KRAS Inhibitor Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones.

Cancer research·2026
Same author

Spatiotemporal mapping of the contractile and adhesive forces sculpting early C. elegans embryos.

Developmental cell·2026
Same author

Cell cycle oscillations in a polarity network facilitate state switching by morphogenetic cues.

Science advances·2026
Same author

Synthetic data enables human-grade microtubule analysis with foundation models for segmentation.

PLoS computational biology·2026
Same author

Benzimidazole inhibits <i>Haemonchus contortus</i> microtubule dynamics by intradimer structural changes observed by <i>in silico</i> modeling.

Journal of biomolecular structure & dynamics·2026
Same author

Adaptations in Plasmodium tubulin determine distinct microtubule architectures, mechanics and drug susceptibility.

Nature communications·2026

Related Experiment Video

Updated: Apr 5, 2026

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation
14:27

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation

Published on: August 8, 2016

8.9K

Intracellular Scaling Mechanisms.

Simone Reber1, Nathan W Goehring2

  • 1Max Planck Institute of Molecular Genetics and Cell Biology, 01307 Dresden, Germany Integrative Research Institute (IRI) for the Life Sciences, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.

Cold Spring Harbor Perspectives in Biology
|August 9, 2015
PubMed
Summary

Organelle size often scales with cell size, especially during rapid early development. This scaling ensures proper cellular function by adjusting organelle-to-cell size ratios, impacting structures like the nucleus and centrosome.

More Related Videos

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila
06:00

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Published on: October 1, 2011

14.5K
Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy
08:17

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy

Published on: August 16, 2021

2.2K

Related Experiment Videos

Last Updated: Apr 5, 2026

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation
14:27

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation

Published on: August 8, 2016

8.9K
Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila
06:00

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Published on: October 1, 2011

14.5K
Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy
08:17

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy

Published on: August 16, 2021

2.2K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Organelle Biology

Background:

  • Organelle function is closely linked to organelle size.
  • The critical factor is often the organelle-to-cell size ratio, not absolute size.
  • Cellular structures must scale to meet increased metabolic demands and facilitate division in larger cells.

Purpose of the Study:

  • To highlight scaling mechanisms for various cellular structures.
  • To differentiate scaling from general cell size control mechanisms.
  • To explore the relationship between organelle size control and cell size.

Main Methods:

  • Review of existing literature on organelle scaling and size control.
  • Analysis of scaling mechanisms for centrosomes, nuclei, and the mitotic spindle.
  • Comparison of size-control mechanisms in relation to cell size.

Main Results:

  • Organelles, including centrosomes and nuclei, often scale with cell size.
  • Scaling is crucial during early development when cell size changes rapidly.
  • Some scaling is a direct outcome of organelle size control mechanisms.

Conclusions:

  • Organelle scaling is essential for maintaining cellular function across different cell sizes.
  • Scaling can be an indirect consequence of cell-size-dependent regulation of size-control mechanisms.
  • Understanding organelle scaling provides insights into fundamental cell biology and development.