Related Experiment Video
Updated: Apr 5, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Reducing Racial Disparities in Influenza Vaccination Among Children With Asthma
Insights
A new intervention significantly boosted influenza vaccination rates in children with asthma. This evidence-based approach also successfully reduced existing racial disparities in vaccination uptake.
Area of Science:
- Pediatric Primary Care
- Immunization Practices
- Public Health Interventions
Background:
- Asthma affects numerous children, increasing their risk for influenza complications.
- Low influenza vaccination rates remain a concern in pediatric populations, particularly among minority groups.
- Targeted interventions are needed to improve vaccine uptake in high-risk pediatric groups.
Purpose of the Study:
- To evaluate the impact of a multifaceted intervention on influenza vaccination rates in children with asthma.
- To assess whether the intervention reduced disparities in vaccination rates based on race.
Main Methods:
- A pre/post study design was employed across 18 primary care practices.
- The intervention involved the "4 Pillars Immunization Toolkit" and additional strategies.
- Influenza vaccination rates were compared before and after the intervention period (2 years), analyzing overall and race-specific data.
Main Results:
- Significant increases in influenza vaccination rates were observed in 13 out of 18 practices.
- Vaccination rates for non-White children rose from 46% to 61% (p < .01).
- Vaccination rates for White children increased from 58% to 65% (p < .001), and pre-intervention racial disparities were eliminated.
Conclusions:
- A comprehensive, evidence-based intervention effectively increased influenza vaccination uptake in children with asthma.
- The intervention successfully mitigated racial disparities in influenza vaccination rates.
- This strategy holds promise for improving immunization coverage in vulnerable pediatric populations.
Introduction:
A multifaceted intervention to raise influenza vaccination rates was tested among children with asthma.
Methods:
In a pre/post study design, 18 primary care practices implemented the 4 Pillars Immunization Toolkit along with other strategies. The primary outcome was the difference in influenza vaccination rates at each practice among children with asthma between the baseline year (before the intervention) and at the end of year 2 (after the intervention), both overall and by race (White vs. non-White).
Results:
Influenza vaccination rates increased significantly in 13 of 18 practices. The percentage of vaccinated non-White children increased from 46% to 61% (p < .01), and the percentage of vaccinated White children increased from 58% to 65% (p < .001). Likelihood of vaccination was significantly lower for non-White children before the intervention (odds ratio = 0.66; 95% confidence interval = 0.59-0.73; p < .001), but this difference was eliminated after the intervention (odds ratio = 0.95; 95% confidence interval = 0.85-1.05; p = .289).
Discussion:
A multi-strategy, evidence-based intervention significantly increased influenza vaccination uptake and reduced racial disparities among children with asthma.
Related Concept Videos
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Nursing Management
First, in...
Asthma-I: Introduction
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

