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Screening for Genetic Testing in Breast Cancer - Are We Missing the Full Picture?

G McCormick1, C Mikropoulos1, G Sadler1

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Clinical Oncology (Royal College of Radiologists (Great Britain))
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Abstract

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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