Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cell Cycle Control System02:11

The Cell Cycle Control System

15.1K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
15.1K
The Cell Cycle Control System01:28

The Cell Cycle Control System

6.4K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
6.4K
The Cell Cycle Control System02:11

The Cell Cycle Control System

9.4K
9.4K
Positive Regulator Molecules01:45

Positive Regulator Molecules

137.2K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
137.2K
Positive Regulator Molecules02:39

Positive Regulator Molecules

7.1K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
7.1K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.7K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis.

Molecular cancer research : MCR·2024
Same author

BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation.

Cell death & disease·2024
Same author

A robust dual gene ON-OFF toggle directed by two independent promoter-degron pairs.

Journal of cell science·2023
Same author

Whole-Genome Duplication and Genome Instability in Cancer Cells: Double the Trouble.

International journal of molecular sciences·2023
Same author

Cyclin A-CDK1 suppresses the expression of the CDK1 activator CDC25A to safeguard timely mitotic entry.

The Journal of biological chemistry·2023
Same author

MARCH5 regulates mitotic apoptosis through MCL1-dependent and independent mechanisms.

Cell death and differentiation·2022

Related Experiment Video

Updated: Apr 5, 2026

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts
06:31

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts

Published on: September 27, 2018

8.7K

Cell Cycle Control: A System of Interlinking Oscillators.

Randy Y C Poon1

  • 1Division of Life Science, Center for Cancer Research, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, rycpoon@ust.hk.

Methods in Molecular Biology (Clifton, N.J.)
|August 10, 2015
PubMed
Summary

Cell cycle progression relies on linked oscillators, like cyclin-dependent kinases, that ensure ordered cell division and genome integrity through auto-amplification and timed inactivation. Checkpoints halt the cell cycle to fix defects, ensuring accurate cell duplication.

More Related Videos

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

2.0K
Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

717

Related Experiment Videos

Last Updated: Apr 5, 2026

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts
06:31

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts

Published on: September 27, 2018

8.7K
Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

2.0K
Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

717

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The cell cycle governs cell duplication, growth, and division.
  • Cyclin-dependent kinases and other kinases drive key cell cycle transitions.
  • Auto-amplifying loops and timed inactivation are crucial regulatory themes.

Purpose of the Study:

  • To elucidate the regulatory mechanisms of cell cycle oscillators.
  • To explain how ordered cell cycle progression and genome integrity are maintained.
  • To describe the interplay between autonomous oscillator activity and checkpoint controls.

Main Methods:

  • Analysis of molecular mechanisms governing cell cycle transitions.
  • Investigation of cyclin-dependent kinase activity and regulation.
  • Examination of protein degradation pathways (ubiquitination) in cell cycle control.
  • Review of cell cycle checkpoint functions.

Main Results:

  • Cell cycle progression is driven by interconnected oscillators, often involving cyclin-dependent kinases.
  • Auto-amplifying loops ensure switch-like transitions, while dephosphorylation and degradation control periodicity.
  • Checkpoint mechanisms provide safeguards against errors during cell cycle progression.

Conclusions:

  • The cell cycle is orchestrated by a network of oscillators with inherent activation and inactivation mechanisms.
  • Interlinked oscillators and checkpoint controls ensure accurate cell division and protect genome integrity.
  • Understanding these mechanisms is vital for comprehending cell proliferation and disease.