Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

5.3K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liquid-liquid phase separation-associated gene networks link EMT and ferroptosis to define a PDGFRB-centered prognostic signature in bladder cancer.

Frontiers in immunology·2026
Same author

An interpretable, clinically-aligned AI paradigm for VTE risk prediction: an approach using LLMs and compound attention.

Computer methods in biomechanics and biomedical engineering·2026
Same author

Geographic distance and climate-mediated landscape resistance explain the genetic differentiation of Rhopalus sapporensis across China.

Molecular phylogenetics and evolution·2026
Same author

Modulating burn wound immunity and vasculature with a photo-crosslinkable glycyrrhizic acid-ginsenoside hydrogel.

Biomedical materials (Bristol, England)·2026
Same author

Deciphering Augmented Dual-ROS-Driven Biofilm Eradication by Facilitating Long-Range Spatial Charge Decoupling in Polymer Carbon Dots.

Angewandte Chemie (International ed. in English)·2026
Same author

O-GlcNAcylation of UGDH: emerging insights into immunometabolic regulation and therapeutic implications.

Cell death discovery·2026

Related Experiment Video

Updated: Apr 5, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

717

Cell Cycle Synchronization Using a Microfluidic Synchronizer for Fission Yeast Cells.

Shujing Wang1, Chunxiong Luo

  • 1The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, 5 Yiheyuan Road, Haidian, Beijing, China.

Methods in Molecular Biology (Clifton, N.J.)
|August 10, 2015
PubMed
Summary
This summary is machine-generated.

This study introduces a novel microfluidic baby machine for synchronizing fission yeast cell cycles. The device effectively immobilizes mother cells, enabling precise collection of age- and phase-synchronized daughter cells for research.

More Related Videos

Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

15.4K
Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae
07:48

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae

Published on: October 11, 2022

2.4K

Related Experiment Videos

Last Updated: Apr 5, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

717
Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

15.4K
Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae
07:48

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae

Published on: October 11, 2022

2.4K

Area of Science:

  • Cell Biology
  • Microfluidics
  • Biotechnology

Background:

  • Cell cycle synchronization is crucial for biological studies.
  • Existing 'baby machine' technologies face challenges with specific cell types like fission yeast.
  • Microfluidic devices offer precise control but require specialized designs for different cell morphologies.

Purpose of the Study:

  • To develop an artifact-free baby machine for synchronizing fission yeast (Schizosaccharomyces pombe) cell cycles.
  • To overcome the immobilization challenges of rod-shaped cells in microfluidic devices.
  • To create an integrated on-chip tool for generating synchronous cell populations.

Main Methods:

  • Design and fabrication of a novel microfluidic device for cell immobilization.
  • Optimization of cell-fixing structures for fission yeast.
  • Integration of a polymer-based cell screener for automated collection.
  • Testing the device's efficacy in producing synchronized cell cultures.

Main Results:

  • Successful immobilization of mother fission yeast cells.
  • Generation of age- and cell-cycle-synchronized daughter cells.
  • Demonstration of a functional integrated cell screener for sample collection.
  • Validation of the device as a tool for producing synchronous cell populations.

Conclusions:

  • The developed baby machine is effective for synchronizing fission yeast.
  • This on-chip tool facilitates cell biology research by providing synchronous cell populations.
  • The device design offers a potential solution for synchronizing other rod-shaped microorganisms.