[An analysis of laboratory results of parameters of organ function in patients with heat stroke]

To explore the role of parameters of organ function during heat stroke ( HS ) on the prognosis, and to form the treatment strategy through an analysis of parameters of organ function during HS.

A retrospective study was conducted. Thirty-seven patients with HS ( HS group ) and 54 patients with mild-to-moderate stroke ( stroke group ) admitted to Zhejiang Xiaoshan Hospital from 2011 to 2014 were enrolled. The experimental results of organs function indicators for patients were recorded including: (1) cardiac markers: troponin I ( TnI ); (2) myocardium zymogram: creatine kinase ( CK ), MB isoenzyme of creatine kinase ( CK-MB ), lactate dehydrogenase ( LDH ), and aspartate aminotransferase ( AST ); (3) renal function indexes: blood urea nitrogen ( BUN ), uric acid ( UA ), and serum creatinine ( SCr ); (4) electrolyte: serum K(+), Na(+), and Cl(-); (5)coagulation function: prothrombin time ( PT ), international normalized ratio ( INR ), activated partial thromboplastin time ( APTT ), thrombin time ( TT ), fibrinogen ( FIB ), and D-dimer; (6) blood gas analysis: pH value, arterial partial pressure of carbon dioxide ( PaCO(2)), base excess ( BE ), standard bicarbonate ( SB ), and actual bicarbonate ( AB ); (7) routine blood test: blood platelet count ( PLT ); (8) hepatic function: alanine aminotransferase ( ALT ). Abnormal rates of laboratory parameters of 37 HS patients were statistically analyzed. Various laboratory parameters of organs function as well as the initial value and extreme value ( maximum or minimum value ) during treatment of CK and PLT in HS patients were compared between two groups.

The abnormal rates of 37 HS patients were more than 70%, including incipient value of TnI, CK, LDH, AST, serum Na(+), ALT, D-dimer, PaCO(2), AB, maximum value of CK, and minimum value of PLT, the abnormal rates being 73.0%, 70.3%, 81.1%, 78.4%, 78.4%, 70.3%, 70.3%, 70.3%, 75.7%, 81.1%, 75.7%, respectively. The abnormal rates of other parameters were less than 70%. There were significant differences in incipient value of TnI, CK, LDH, AST, serum K(+), serum Na(+), D-dimer, and PLT between HS group and mild-to-moderate stroke group [ TnI ( μg/L ): 0.087 ( 0.026, 0.306 ) vs. 0.007 ( 0.004, 0.110 ), Z = -7.017, P = 0.000; CK ( U/L ): 392.30 ( 287.60, 524.10 ) vs. 137.10 ( 106.33, 607.80 ), Z = -7.930, P = 0.000; LDH ( U/L ): 317.98±122.74 vs. 207.85±57.71, t = 1.678, P = 0.000; AST ( U/L ): 94.90 ( 52.80, 155.80 ) vs. 26.10 ( 18.13, 317.40 ), Z = -6.157, P = 0.000; serum K(+) ( mmol/L ): 3.46±0.65 vs. 3.86±0.57, t = 1.662, P = 0.001; serum Na(+) ( mmol/L ): 129.75±7.34 vs. 138.79±4.26, t = 1.674, P = 0.000; D-dimer ( mg/L ): 2.53 ( 0.63, 6.00 ) vs. 0.30 ( 0.21, 9.71 ), Z = -5.084, P = 0.000; PLT ( ×10(9)/L ): 144.62±86.14 vs. 219.48±64.76, t = 1.669, P = 0.000 ]. There were also statistically significant differences in the initial value and extreme value of CK and PLT between HS group and mild-to-moderate stroke group [ CK ( U/L ): 392.30 ( 287.60, 524.10 ) vs. 721.50 ( 546.30, 964.10 ), Z = -6.351, P = 0.000; PLT ( ×10(9)/L ): 132.40±82.55 vs. 68.24±44.62, t = 1.688, P = 0.000 ].

HS can impair several organs and systems, having complications, and it is a heavy insult for body. Increasing of CK and decreasing of PLT has some value to assess illness changes. It is helpful of laboratory results for doctors to estimate complications on time.