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Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study
Stéphane Potvin1, Andràs Tikàsz1, Ovidiu Lungu2
1Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada.
Objectives:
To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR).
Methods:
Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images.
Results:
Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups.
Conclusions:
Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.
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