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Cocaine Profiling Methodology - Recent Advancesk.

J M Moore1, J F Casale1

  • 1Special Testing and Research Laboratory, US Drug Enforcement Administration, McLean, VA, USA.

Forensic Science Review
|August 11, 2015
PubMed
Summary

New cocaine profiling methods enhance detection of alkaloidal impurities in illicit drugs. This advanced technique improves the analysis of cocaine and its related compounds for forensic applications.

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Area of Science:

  • Forensic Chemistry
  • Analytical Chemistry

Background:

  • Current cocaine signature analysis methods have limitations in detecting trace alkaloidal impurities.
  • The U.S. Drug Enforcement Administration's Special Testing and Research Laboratory employs established procedures for cocaine profiling.

Purpose of the Study:

  • To develop and describe a novel, selective, and sensitive methodology for cocaine profiling.
  • To identify and quantify a broader range of alkaloidal impurities in refined illicit cocaine.

Main Methods:

  • Alumina column chromatography was used to isolate alkaloidal impurities from the cocaine matrix.
  • Capillary gas chromatography-mass selective detection in selected ion mode was employed for sensitive detection.
  • The methodology was applied to 51 refined illicit cocaine samples, analyzing 15 selected alkaloids.
Keywords:
CocaineGas chromatography/Mass spectrometryprofilingsignature

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Main Results:

  • The developed methodology successfully detected more alkaloidal impurities in refined illicit cocaine than previously reported.
  • Reproducibility data were established for the analysis of 15 selected alkaloids.
  • The study reviewed methods for isolating, detecting, and characterizing coca alkaloids from various sources.

Conclusions:

  • The new cocaine profiling methodology offers enhanced sensitivity and selectivity for impurity detection.
  • This advancement improves the forensic analysis of illicit cocaine and related materials.
  • The findings contribute to more comprehensive cocaine signature analysis.