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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Assessing Specificity of Anticancer Drugs In Vitro
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Oral antineoplastic agents: how do we care about adherence?

Marie Barillet1, Virginie Prevost2,3,4, Florence Joly2,3,4

  • 1Centre Hospitalier J Monod, rue Eugène Garnier BP 219, 61104, Flers cedex.

British Journal of Clinical Pharmacology
|August 11, 2015
PubMed
Summary

Adherence to oral anticancer therapies varies widely and depends on assessment methods. Improving long-term patient adherence requires standardized methods and defined strategies in oncology practice.

Keywords:
antineoplastic agentscancer chemotherapy agentsmedication adherencemolecular targeted therapiespatient compliance

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Area of Science:

  • Oncology
  • Pharmacology
  • Health Services Research

Background:

  • Oral anticancer therapies, including hormone-based and targeted treatments, are increasingly used in cancer care.
  • Patient adherence to these oral medications is crucial for treatment efficacy but remains a significant challenge.

Purpose of the Study:

  • To review the association between adherence assessment methods and measured adherence rates.
  • To identify factors influencing patient adherence to oral anticancer therapies.
  • To explore novel strategies for enhancing adherence in clinical practice.

Main Methods:

  • A literature-based narrative review was conducted using PubMed.
  • Search terms combined concepts of oral anticancer medications and patient adherence.
  • Analysis included 48 studies published since 1990.

Main Results:

  • Adherence rates varied significantly (14%–100%) and were influenced by the assessment method used.
  • Patient-related factors and discrepancies in adherence definitions impacted reported rates.
  • Persistence generally decreased over time, indicating a decline in adherence.

Conclusions:

  • Standardizing adherence assessment methods is essential for clinical studies.
  • Further research is needed to define optimal strategies for improving long-term adherence to oral cancer therapies.
  • Addressing adherence is a critical issue in managing patients on novel oral anticancer treatments.