[Protective effect of specific human immunoglobulins on haematogenous osteomyelitis by Staphylococcus aureus in mice]

Effects of specific human immunoglobulins extracted from pooled human sera on the protection of the production of haematogenous osteomyelitis by a strain of Staphylococcus aureus in mice were studied. No multiplication of the organisms in mouse bone marrow was observed by intravenous injection of strain SMU01 of Staphylococcus aureus when 2.20mg protein of specific immunoglobulins was administered prior to the injection of the strain. Roentgenographic examinations in mice revealed no destructive findings around the proximal and distal metaphysis of the femur at one to two weeks after the injection, indicating absence of macroscopic abscess formation in these area. These results suggest a possible therapeutic effect of specific human immunoglobulins on human staphylococcal osteomyelitis.