Related Experiment Video

Updated: Apr 5, 2026

Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres
09:31

Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres

Published on: January 29, 2018

8.1K

Epigenetic deregulations in chordoma

Xin Yu1, Zheng Li1

  • 1Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.

Cell Proliferation
|August 11, 2015
PubMed

Insights

Chordoma, a rare bone cancer, has poor prognosis due to poorly understood molecular mechanisms. Epigenetic alterations are implicated in chordoma pathogenesis and may offer new diagnostic and therapeutic strategies.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Chordoma is a rare malignant bone tumor originating from notochordal remnants.
  • The molecular and genetic underpinnings of chordoma remain poorly understood, contributing to a poor patient prognosis.
  • Epigenetic mechanisms, including DNA methylation, histone modification, and nucleosome remodeling, are increasingly recognized for their role in disease pathogenesis.

Purpose of the Study:

  • To review current epigenetic findings related to chordoma.
  • To explore the potential of epigenetic alterations as diagnostic and prognostic biomarkers.
  • To discuss epigenetic modifications as potential therapeutic targets for chordoma treatment.

Main Methods:

  • Literature review of epigenetic mechanisms in chordoma.
  • Analysis of studies investigating DNA methylation, histone modification, and nucleosome remodeling in chordoma.
  • Synthesis of findings on the clinical relevance of epigenetic alterations.

Main Results:

  • Aberrant epigenetic patterns are observed in chordoma patients.
  • Epigenetic alterations are implicated in the pathogenesis of this malignancy.
  • Epigenetic modifications show promise for developing novel biomarkers and therapeutic strategies.

Conclusions:

  • Epigenetic mechanisms play a significant role in chordoma development.
  • Targeting epigenetic alterations could lead to improved diagnostic, prognostic, and therapeutic outcomes for chordoma patients.

More Related Videos

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.0K
CRISPR-Mediated Reorganization of Chromatin Loop Structure09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

13.2K

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.2K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.3K
Epigenetic Regulation01:46

Epigenetic Regulation

26.3K
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K