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Related Experiment Video

Updated: Apr 5, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Alginate-hyaluronan composite hydrogels accelerate wound healing process.

O Catanzano¹, V D'Esposito², S Acierno³

¹Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.

Carbohydrate Polymers

|August 11, 2015

Summary

Alginate-hyaluronan hydrogels enhance dermal wound repair. These biofunctional dressings promote faster wound closure in vitro and in vivo, offering a promising clinical strategy for healing.

Keywords:

Alginate Hyaluronan Internal gelation Wound dressing

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Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

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Published on: August 21, 2021

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Dermal wound repair remains a significant clinical challenge.
Polysaccharide-based hydrogels offer potential as advanced wound dressings.
Alginate (ALG) and hyaluronan (HA) are biocompatible polymers with therapeutic potential.

Purpose of the Study:

To develop and characterize alginate-hyaluronan (ALG/HA) hydrogels as biofunctional platforms for dermal wound repair.
To evaluate the effect of HA on ALG hydrogel properties and gelation kinetics.
To assess the in vitro and in vivo efficacy of ALG/HA hydrogels in promoting wound healing.

Main Methods:

Hydrogels were synthesized using internal gelation of ALG/HA mixtures.
Rheological analysis was performed to study gelation kinetics.
In vitro studies involved adipose derived multipotent adult stem cells (Ad-MSC) and HaCaT cells using scratch assays.
In vivo studies utilized a rat model of excised wound.

Main Results:

ALG/HA hydrogels exhibited homogeneous and easy-to-handle properties.
Hyaluronan incorporation slowed gelation kinetics but minimally affected final cross-link density.
ALG/HA hydrogels significantly promoted cell migration (gap closure) in vitro compared to ALG alone.
In vivo studies demonstrated significantly accelerated wound closure with ALG/HA hydrogels in a rat model.

Conclusions:

ALG/HA hydrogels represent a versatile and effective biofunctional platform for dermal wound repair.
The integration of HA into ALG hydrogels enhances their wound healing capabilities.
These findings suggest a promising, clinically translatable strategy for improving wound healing outcomes.