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IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.
Zunqiong Ke1, Leyong Yuan2, Jun Ma3
1Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China.
Yonsei Medical Journal
|August 11, 2015
Summary
Interleukin gene polymorphisms show varied associations with tuberculosis risk. Interleukin-6 (IL-6) may decrease susceptibility, while certain Interleukin-10 (IL-10) variants increase risk in specific ethnic groups.
Area of Science:
- Genetics and Immunology
- Infectious Disease Epidemiology
Background:
- Genetic variations in cytokine genes, specifically interleukin-10 (IL-10) and interleukin-6 (IL-6), are investigated for their potential role in tuberculosis (TB) susceptibility.
- Previous studies on the association between IL-10 (-1082G/A, -819C/T, -592A/C) and IL-6 (-174G/C) polymorphisms and TB risk have yielded conflicting results.
- A comprehensive meta-analysis is needed to clarify the inconsistent findings and establish the precise relationship between these polymorphisms and TB risk.
Purpose of the Study:
- To systematically evaluate the association between specific polymorphisms in IL-10 and IL-6 genes and the risk of developing tuberculosis.
- To resolve controversies in existing literature regarding the genetic influence of IL-10 and IL-6 polymorphisms on TB susceptibility.
- To provide a clearer understanding of the genetic underpinnings of TB risk through meta-analysis.
Main Methods:
- A systematic literature search was conducted across major scientific databases including PubMed, Medline, Embase, Web of Science, Science Direct, and Cochrane Library.
- Studies reporting outcome data on the association between IL-10 and IL-6 polymorphisms and TB risk were identified and included.
- Meta-analysis techniques were employed to synthesize data from eligible studies and estimate the overall effect of polymorphisms on TB risk.
Main Results:
- The interleukin-6 (IL-6) -174G/C polymorphism was significantly associated with a decreased risk of TB across allele, heterozygous, and dominant models.
- Stratified analyses revealed that IL-10 -1082G/A polymorphism increased TB risk in Europeans (recessive model), while IL-10 -819C/T and -592A/C polymorphisms increased risk in Asians (various models).
- Conversely, the IL-6 -174C/G polymorphism showed a decreased TB risk in Asians (allele, heterozygous, and dominant models).
Conclusions:
- The IL-10 -1082G/A polymorphism is linked to an elevated TB risk in European populations.
- IL-10 -819C/T and -592A/C polymorphisms are associated with increased TB risk specifically in Asian populations.
- The IL-6 -174G/C polymorphism may act as a protective genetic factor, reducing TB susceptibility, particularly in individuals of Asian descent.
