Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Two brothers with reflux nephropathy].

N Eryu, N Akano, H Miyamoto

    Nihon Jinzo Gakkai Shi
    |November 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Biodegradable scleral implant for intravitreal controlled release of fluconazole.

    Current eye research·1997
    Same author

    Ki-67 labeling indices in non-small cell lung cancer: comparison between image cytometry and flow cytometry.

    Cytometry·1997
    Same author

    Analysis of p21Waf1/Cip1 expression in normal, premalignant, and malignant cells during the development of human lung adenocarcinoma.

    The American journal of pathology·1997
    Same author

    Monoclonal antibodies against pig ovarian follicular granulosa cells induce apoptotic cell death in cultured granulosa cells.

    The Journal of veterinary medical science·1997
    Same author

    Lectin histochemistry in rat liver fibrosis induced by heterologous serum sensitization.

    The Journal of veterinary medical science·1997
    Same author

    [Serological differences in Helicobacter pylori].

    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases·1997

    Two brothers with reflux nephropathy showed kidney function decline and proteinuria. Their HLA-A9 gene type was linked to the disease

    Area of Science:

    • Nephrology
    • Genetics
    • Immunology

    Background:

    • Reflux nephropathy is a kidney disease often diagnosed in childhood.
    • Early detection and understanding of disease progression are crucial for managing kidney function.

    Observation:

    • Two brothers presented with proteinuria and declining renal function.
    • Diagnostic imaging (DIP, VCG) and renal biopsy confirmed reflux nephropathy.

    Findings:

    • Renal biopsy revealed focal segmental sclerosis, IgM deposition, and glomerular basement membrane damage.
    • HLA typing identified HLA-A9 in both brothers and their mother, a known risk factor.

    Implications:

    • The HLA-A9 association suggests a genetic predisposition to progressive reflux nephropathy.

    Related Experiment Videos

  • This finding may aid in identifying at-risk individuals and developing targeted therapies.