[Two brothers with reflux nephropathy]

This paper reports two brothers with reflux nephropathy. Patients who were 10-year-old and 12-year-old were referred to our hospital due to proteinuria and deterioration of renal function. Diagnosis of reflux nephropathy was made on drip infusion pyelography (DIP), voiding cystogram (VCG), and renal biopsy findings. The following findings were observed in renal tissues; focal and segmental sclerosis by light microscopy, IgM deposition by immunofluorescent microscopy, and glomerular basement membrane alterations and detachment of podocytes by electron microscopy. The HLA typing and analysis showed that both brothers and their mother possessed HLA-A9, which is reported to be closely associated with progression of primary reflux nephropathy to end-stage renal disease.