Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Representativeness Heuristic02:13

The Representativeness Heuristic

17.1K
The representative heuristic describes a biased way of thinking, in which you unintentionally stereotype someone or something. For example, you may assume that your professors spend their free time reading books and engaging in intellectual conversation, because the idea of them spending their time playing volleyball or visiting an amusement park does not fit in with your stereotypes of professors.
17.1K
Concepts and Prototypes01:24

Concepts and Prototypes

650
The human nervous system handles vast amounts of information by translating sensory stimuli into neural impulses, which the brain processes, creating thoughts expressed through language or stored as memories. The brain also synthesizes information from emotions and memories, which significantly influence thoughts and behaviors. This intricate process creates a comprehensive mental picture.
The brain organizes this information using concepts, which are mental categories grouping linguistic data,...
650
Cluster Sampling Method01:20

Cluster Sampling Method

15.6K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
15.6K
Multiple Allele Traits01:49

Multiple Allele Traits

38.9K
The Concept of Multiple Allelism
38.9K
Multiple Allele Traits01:49

Multiple Allele Traits

15.0K
15.0K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

407
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
407

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell Cycle Sensing Shapes Human T Cell Fate and Exhaustion Programs.

bioRxiv : the preprint server for biology·2026
Same author

Wavelet Decomposition-Based Genomic Analysis of the Human Electrocardiogram.

medRxiv : the preprint server for health sciences·2026
Same author

Structure-preserving multivariate hypothesis testing for mass spectrometry imaging and single-cell data.

Bioinformatics (Oxford, England)·2026
Same author

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition in metastatic TNBC.

Nature cancer·2026
Same author

Prognostic pan-cancer and single-cancer models: A large-scale analysis using a real-world clinico-genomic database.

PloS one·2026
Same author

Glaucoma Classification Through SSVEP-Derived ON- and OFF-Pathway Features.

Translational vision science & technology·2026

Related Experiment Video

Updated: Apr 5, 2026

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
12:27

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Published on: February 15, 2017

7.4K

Hierarchical Clustering With Prototypes via Minimax Linkage.

Jacob Bien1, Robert Tibshirani2

  • 1Department of Statistics, Stanford University, Stanford, CA 94305.

Journal of the American Statistical Association
|August 11, 2015
PubMed
Summary

Minimax linkage enhances hierarchical clustering interpretability by associating data prototypes with dendrogram nodes. This novel method offers theoretical benefits and practical applications in data analysis and visualization.

Keywords:
AgglomerativeDendrogramUnsupervised learning

More Related Videos

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

3.1K

Related Experiment Videos

Last Updated: Apr 5, 2026

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
12:27

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Published on: February 15, 2017

7.4K
A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

3.1K

Area of Science:

  • Data Science
  • Machine Learning
  • Computational Statistics

Background:

  • Agglomerative hierarchical clustering is widely used for dataset structure analysis.
  • Cluster distance measurement, or linkage, significantly impacts clustering outcomes.
  • Existing linkage methods may lack interpretability or possess undesirable properties.

Purpose of the Study:

  • To investigate minimax linkage, a novel and understudied hierarchical clustering linkage method.
  • To demonstrate the unique interpretability benefits of minimax linkage through associated data prototypes.
  • To evaluate the theoretical properties and practical utility of minimax linkage.

Main Methods:

  • Introduced and defined minimax linkage for agglomerative hierarchical clustering.
  • Proved theoretical properties, including resistance to inversions and robustness to perturbations.
  • Developed an efficient implementation of the minimax linkage algorithm.

Main Results:

  • Minimax linkage naturally associates data prototypes with dendrogram interior nodes, enhancing interpretability.
  • Demonstrated that minimax linkage dendrograms do not exhibit inversions, unlike centroid linkage.
  • Showcased minimax linkage's effectiveness on real-world datasets, including text and image data.

Conclusions:

  • Minimax linkage offers significant advantages in hierarchical clustering, particularly in interpretability and theoretical robustness.
  • The method provides a valuable tool for data analysis and visualization, enhancing understanding of complex datasets.
  • Further exploration of minimax linkage is warranted due to its unique properties and demonstrated utility.