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An update on testosterone, HDL and cardiovascular risk in men

Arthi Thirumalai1, Katya B Rubinow2, Stephanie T Page3

  • 1University of Washington, Division of Metabolism, Endocrinology & Nutrition, 1959 NE Pacific Street, Box 356426, Seattle, WA 98195, USA.

Clinical Lipidology
|August 11, 2015
PubMed

Insights

Testosterone replacement therapy

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Men's Health

Background:

  • Rising testosterone prescriptions in the USA lack clear cardiovascular risk understanding.
  • Age-related testosterone decline correlates with increased cardiovascular disease risk.
  • Observational data suggest links between hypogonadism and cardiovascular disease, but testosterone replacement therapy (TRT) efficacy is unproven.

Purpose of the Study:

  • To review current literature on the relationship between testosterone and cardiovascular disease.
  • To investigate the effects of testosterone on lipids, particularly HDL, and their potential role in cardiovascular outcomes.

Main Methods:

  • Literature review of existing studies on testosterone and cardiovascular disease.
  • Analysis of research examining testosterone's impact on lipid profiles, including HDL cholesterol.

Main Results:

  • Recent literature raises concerns about increased cardiovascular disease risk in some men on TRT.
  • The precise relationship between androgens and cardiovascular health remains unclear.
  • Testosterone's specific effects on HDL cholesterol warrant further investigation in relation to clinical cardiovascular effects.

Conclusions:

  • The cardiovascular safety and efficacy of testosterone replacement therapy require further rigorous investigation.
  • Understanding the impact of testosterone on lipid metabolism is crucial for assessing cardiovascular risk.
  • More research is needed to clarify the complex interplay between testosterone, androgens, and cardiovascular disease.

Keywords:
HDLcardiovascular diseasemale hypogonadismtestosteronetestosterone replacement therapy (TRT)

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