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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
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Update on deep brain stimulation in Parkinson's disease
Daniel Martinez-Ramirez1, Wei Hu1, Alberto R Bona2
1Department of Neurology, University of Florida, College of Medicine, Center for Movement Disorders and Neurorestoration, 3450 Hull Road, Gainesville, FL 32607 USA.
Translational Neurodegeneration
|August 11, 2015
Summary
Deep brain stimulation (DBS) offers a safe surgical option for Parkinson's disease (PD) and movement disorders. This therapy enhances motor function and quality of life by modulating neural networks.
Area of Science:
- Neurosurgery
- Neurology
- Movement Disorders
Background:
- Deep brain stimulation (DBS) is a well-tolerated surgical intervention for Parkinson's disease (PD) and other movement disorders.
- While its exact mechanism remains unclear, DBS significantly improves motor functions and quality of life in select patients.
Purpose of the Study:
- To review recent literature on DBS therapy for PD.
- To highlight cutting-edge advances and evidence supporting DBS in neural network modulation for PD.
Main Methods:
- Review of recent scientific literature on DBS for Parkinson's disease.
- Analysis of established and emerging DBS targets and indications.
Main Results:
- Established DBS targets for PD include the globus pallidus pars interna and subthalamic nucleus.
- Other targets like ventralis intermedius and zona incerta are used for tremor-dominant PD.
- The pedunculopontine nucleus (PPN) is being investigated for gait and postural instability.
Conclusions:
- DBS is a valuable therapeutic option for carefully selected PD patients, improving motor symptoms and quality of life.
- Ongoing research explores new targets like PPN for specific PD symptoms, advancing neural network modulation strategies.
Keywords:
Brain modulationClosed-loopGlobus pallidusMovement disordersNeural networkSubthalamic nucleus
