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Updated: Apr 5, 2026

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
Published on: May 4, 2021
Role of microRNA biogenesis in adipocyte and lipodystrophy
1Cardiovascular and Metabolic Disorders; Duke-National University of Singapore Graduate Medical School ; Singapore.
Abstract:
The detailed mechanism underlying adipocyte development and function remains to be fully understood. MicroRNAs are a class of non-coding regulators in adipocyte development and function in physiological and pathological conditions. Our recent study(11) using adipose-specific dgcr8 knockout mice demonstrates that microRNA biogenesis has a depot-specific function in adipose and plays an important role in brown adipocyte feature maintenance. Interestingly, in a parallel study from Kahn's group, Mori et al observed similar phenotypes in adipose-specific Dicer knockout mice. This study also reveals that the expression of Dicer is downregulated in the adipose from patients with HIV-associated lipodystrophy (HALS), suggesting that dysregulation of microRNA biogenesis may play a role in the onset of HALS.
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