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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

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Dual agents loaded polymeric nanoparticle: Effect of process variables.

Deepak Sharma¹, Gilphy Philip¹, Reema Gabrani¹

¹Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India.

International Journal of Pharmaceutical Investigation

|August 11, 2015

Summary

Polymeric nanoparticles loaded with hesperidin and diazepam were successfully formulated and optimized. These nanoparticles demonstrated controlled drug release and reduced cytotoxicity, indicating their potential for improved drug delivery.

Keywords:

Polymeric nanoparticles Three levels factorial design diazepam hesperidin optimization

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Area of Science:

Pharmaceutical Nanotechnology
Drug Delivery Systems

Background:

Polymeric nanoparticles (NPs) offer a promising platform for encapsulating therapeutic agents.
Hesperidin and diazepam are active pharmaceutical ingredients with distinct therapeutic applications.

Purpose of the Study:

To formulate and optimize dual-agent polymeric nanoparticles (NPs) co-encapsulating hesperidin and diazepam.
To evaluate the in vitro drug release and safety profile of the developed NPs.

Main Methods:

Nanoprecipitation method was employed for NP formulation.
A three-level factorial design was used to optimize poly(lactic-co-glycolic) acid (PLGA) and poloxamer content.
In vitro drug release and cell viability assays (Vero cell line) were conducted.

Main Results:

Optimized NPs exhibited z-average in the range of 189-307 d.nm.
High drug entrapment efficiencies were achieved for both diazepam (62-89%) and hesperidin (68-92%).
Polymeric NPs demonstrated controlled in vitro drug release and reduced cytotoxicity compared to aqueous solutions.

Conclusions:

The developed polymeric NPs effectively co-encapsulate hesperidin and diazepam.
The NPs show potential for sustained drug release and improved safety profile in drug delivery applications.