Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Chemosensitivity study using subrenal capsule assay in urinary transitional cell carcinomas].

K Kobashi

    Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
    |December 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Down-regulation of IL-18 receptor in cancer patients: its clinical significance.

    Anticancer research·2002
    Same author

    Cathepsin L activity and its inhibitor in human otitis media.

    The Journal of otolaryngology·2002
    Same author

    Clinical approach to renal study incidental to 99mTc-MDP bone scintigraphy.

    Annals of nuclear medicine·2001
    Same author

    Pubovaginal slings: a review of the technical variables.

    Current opinion in urology·2001
    Same author

    [Early phase II study of amrubicin (SM-5887) for superficial bladder cancer: a dose-finding study for intravesical chemotherapy].

    Gan to kagaku ryoho. Cancer & chemotherapy·2001
    Same author

    Participation of IL-18 in human cholestatic cirrhosis and acute rejection: analysis in living donor liver transplantation.

    Transplantation proceedings·2001

    The subrenal capsule assay effectively grows urinary transitional cell carcinoma (TCC) explants, showing drug susceptibility. The delta TS method is more practical for assessing chemotherapy effectiveness in TCC patients.

    Area of Science:

    • Urology
    • Oncology
    • Cancer Research

    Context:

    • Urinary transitional cell carcinoma (TCC) is a significant malignancy.
    • Accurate assessment of TCC drug susceptibility is crucial for effective treatment.
    • The subrenal capsule assay (SRCA) offers a model for studying tumor behavior.

    Purpose:

    • To evaluate the efficacy of the subrenal capsule assay (SRCA) for growing urinary TCC explants.
    • To assess the drug susceptibility of TCC using the delta TS method and compare it with the tumor growth inhibition rate (TGIR) method.
    • To investigate the correlation between tumor cell proliferation and drug susceptibility.

    Summary:

    • The SRCA successfully cultured 97.7% of urinary TCC explants, with 45.6% showing microscopic tumor growth.

    Related Experiment Videos

  • Drug susceptibility was observed for cisplatin (33%), adriamycin (41%), methotrexate (32%), and cyclophosphamide (29%) via the delta TS method.
  • The delta TS method demonstrated a positive correlation with S-phase cells and proved more practical than TGIR, especially for interstitial tissue-rich tumors.

    • Impact:

    • The SRCA provides a reliable method for evaluating TCC drug sensitivity.
    • The delta TS method is a practical approach for predicting patient response to chemotherapy.
    • Findings support the potential of combined therapies like cisplatin and adriamycin for TCC treatment.