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Primary refractory diffuse large B cell lymphoma in the rituximab era
Clémentine Sarkozy1, Bertrand Coiffier
1Hospices Civils de Lyon, Service d'Hématologie, Pierre Bénite, France.
Purpose Of Review:
The aim of this review is to describe the outcome of primary refractory diffuse large B cell lymphoma in the rituximab era and the different therapeutic options as well as new biological markers that could allow the pathologist to distinguish these cases at diagnosis.
Recent Findings:
Diffuse large B cell lymphoma outcome has been impressively improved since the introduction of rituximab in association with anthracycline-based chemotherapy; however, primary refractory patients still represent an unmet medical need.
Summary:
If patients without relapse after 2 years from diagnosis have an outcome comparable to healthy individuals, primary refractory patients still represent 20% of the cases with a very poor overall survival. These cases are usually described as progressive patients during first line or patients reaching a nonadequate partial response or those relapsing within a year after reaching a response.
