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Updated: Apr 5, 2026

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
Published on: March 22, 2018
SpeedSeq: ultra-fast personal genome analysis and interpretation
Colby Chiang1,2, Ryan M Layer3,4, Gregory G Faust2
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
Abstract:
SpeedSeq is an open-source genome analysis platform that accomplishes alignment, variant detection and functional annotation of a 50× human genome in 13 h on a low-cost server and alleviates a bioinformatics bottleneck that typically demands weeks of computation with extensive hands-on expert involvement. SpeedSeq offers performance competitive with or superior to current methods for detecting germline and somatic single-nucleotide variants, structural variants, insertions and deletions, and it includes novel functionality for streamlined interpretation.
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