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Aptamers against pathogenic microorganisms.

Anna Davydova1, Maria Vorobjeva1, Dmitrii Pyshnyi1

  • 1a Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences , Novosibirsk , Russia and.

Critical Reviews in Microbiology
|August 11, 2015
PubMed
Summary
This summary is machine-generated.

Nucleic acid aptamers offer a promising solution for infectious disease diagnostics and therapy. These molecules can specifically recognize and block bacteria, protozoa, and viruses, leading to new detection systems and drugs.

Keywords:
Antiviral and antimicrobial agentsSELEXaptasensorsnucleic acid aptamerspathogen detection

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Area of Science:

  • Molecular Medicine
  • Biotechnology
  • Infectious Diseases

Background:

  • Developing early diagnostic assays and effective therapies for infectious diseases remains a critical challenge.
  • Nucleic acid aptamers present a novel approach for specific recognition and functional blocking of pathogens.

Purpose of the Study:

  • To review modern Systematic Evolution of Ligands Exponential Enrichment (SELEX) techniques.
  • To summarize identified aptamers against viral particles and unicellular organisms.
  • To discuss the application prospects of aptamers in diagnostics and therapeutics.

Main Methods:

  • Review of various modern SELEX techniques.
  • Identification and summarization of existing aptamers against infectious agents.
  • Analysis of aptamer applications in detection and therapy.

Main Results:

  • SELEX techniques have advanced the development of aptamers.
  • Several aptamers targeting viruses and unicellular organisms have been identified.
  • Aptamers show potential for specific pathogen recognition and functional inhibition.

Conclusions:

  • Nucleic acid aptamers are valuable tools for molecular medicine and biotechnology.
  • Aptamers hold significant promise for developing novel diagnostic systems.
  • Aptamers offer a potential pathway for creating new antibacterial and antiviral drugs.