Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

5.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.1K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.9K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

4.1K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.1K
The Bronchial Tree01:23

The Bronchial Tree

8.3K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
8.3K
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

37
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
37
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment outcomes of drug-resistant tuberculosis in Sabah, Malaysia - a retrospective cohort study.

Public health in practice (Oxford, England)·2025
Same author

Otitis media at 6-monthly assessments of Australian First Nations children between ages 12-36 months: Findings from two randomised controlled trials of combined pneumococcal conjugate vaccines.

International journal of pediatric otorhinolaryngology·2023
Same author

Disease burden, comorbidities and antecedents of chronic cough phenotypes in Australian adults.

Pulmonology·2023
Same author

BOS is associated with decreased HDAC2 from steroid resistant lymphocytes in the small airways.

Clinical and experimental immunology·2018
Same author

Working while unwell: Workplace impairment in people with severe asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2018
Same author

Advancing the management of obstructive airways diseases through translational research.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2018

Related Experiment Video

Updated: Apr 5, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

8.3K

Increased Peripheral Blood Pro-Inflammatory/Cytotoxic Lymphocytes in Children with Bronchiectasis.

G Hodge1, J W Upham2, A B Chang3

  • 1Lung Research, Hanson Institute and Dept. Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia.

Plos One
|August 11, 2015
PubMed
Summary

Childhood bronchiectasis involves increased systemic pro-inflammatory and cytotoxic lymphocytes in the blood, particularly in Indigenous children. Further research is needed to link these elevated cell levels to future health conditions.

More Related Videos

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.6K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.1K

Related Experiment Videos

Last Updated: Apr 5, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

8.3K
Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.6K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.1K

Area of Science:

  • Immunology
  • Pediatric Pulmonology
  • Systemic Inflammation

Background:

  • Bronchiectasis (BE) is prevalent in Australian Indigenous children, yet systemic inflammation is poorly understood.
  • Specific pro-inflammatory and cytotoxic lymphocyte subsets (T-cells, NK cells, NKT-like cells) roles are unclear in childhood BE.
  • Previous studies show elevated cytotoxic/inflammatory mediators in adult lung diseases.

Purpose of the Study:

  • To investigate systemic inflammation in children with bronchiectasis.
  • To quantify pro-inflammatory and cytotoxic mediators in specific lymphocyte subsets.
  • To compare these changes between Indigenous and non-Indigenous children with BE.

Main Methods:

  • Flow cytometry analyzed intracellular mediators (perforin, granzyme b) and cytokines (IFNγ, TNFα).
  • Samples were from blood and bronchoalveolar lavage (BAL) of 12 children with BE and 10 controls.
  • T cell subsets, NKT-like cells, and NK cells were examined.

Main Results:

  • Children with BE showed significantly higher percentages of CD8+ T cells and T/NKT-like subsets expressing perforin/granzyme and IFNγ/TNFα in blood.
  • Indigenous children with BE had a further increase in pro-inflammatory cytotoxic T cells compared to non-Indigenous children.
  • No significant changes in these mediators were observed in BAL samples.

Conclusions:

  • Childhood bronchiectasis is linked to heightened systemic pro-inflammatory and cytotoxic lymphocytes in peripheral blood.
  • Elevated levels of these cells may indicate increased risk for future comorbidities.
  • Further studies are warranted to explore the predictive value of these inflammatory markers.