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Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation

Joanne Kotsopoulos¹, Jan Lubinski², Susan L Neuhausen³

¹Women's College Research Institute, 790 Bay Street, Room 750, Toronto, ON, M5G 1N8, Canada.

Women'S Health (London, England)

|August 11, 2015

Abstract

Aim:

To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy.

Patients & Methods:

We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy.

Results:

There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78).

Conclusion:

Oophorectomy is not associated with significant weight gain in high-risk women.

Keywords:

BRCA1 BRCA2 oophorectomy weight gain

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