Related Experiment Video
Updated: Aug 13, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
[A computer program for the drug dosage of patients with chronic kidney failure]
Abstract:
On the basis of the formula Mt = Mo.e-(Cl/Vd).t, a computer program was developed for estimating the maintenance drug dose in patients with chronic renal failure, depending on the creatinine clearance levels and the body mass. The hypothesis of the intact nephron and the presumption that in chronic renal failure the extrarenal clearance of the drugs does not change is considered a precondition. Any drug whose distribution volume and extrarenal clearance are known may be implicated in the program. The program may also help to determine the additional dose after hemodialysis, depending on the duration of the dialysis and the dialysis clearance of the drug.
Related Concept Videos
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
Chronic Kidney Disease III: Interprofessional Care

