[Psoriasis: how the epithelium influences the immune response: keratinocytes, dendritic cells and T lymphocytes]

Psoriasis is an autoinflammatory skin disease mediated by interactions between keratinocytes, dendritic cells and T lymphocytes, which create a vicious circle of cell activation and lead to the development and persistence of skin lesions. Inflammatory cytokines produced by these three cell types, especially TNFα, IL-23 and IL-17, are central to the disease and are the targets of new, highly effective immunobiological therapies. Advances in the pathophysiology and treatment of psoriasis have applications far beyond the skin disease itself Indeed, psoriasis serves as a model for studies of the mechanisms of chronic inflammation such as rheumatoid arthritis, Crohn's disease, atherosclerosis and type 2 diabetes, and for developing new targeted therapies for autoinflammatory diseases.