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Updated: Apr 5, 2026

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Published on: February 5, 2019
Constitutive and Inducible Expression of the rRNA Methylase Gene erm(B) in Campylobacter
Fengru Deng1, Jianzhong Shen2, Maojun Zhang3
1National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University, Beijing, China College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Abstract:
Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients and food-producing animals. Constitutive expression of erm(B) was associated with insertion and deletion in the regulatory region of the gene, providing the first documentation of the differential expression of erm(B) in Campylobacter bacteria.
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