Breakdown of the striatal-default mode network loop in schizophrenia
Xiangpeng Wang1, Fenghua Li1, Hanfeng Zheng2
1Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China.
Schizophrenia Research
|August 12, 2015
Summary
Schizophrenia disrupts brain communication. This study found a broken connection loop between the striatum and the default mode network (DMN), suggesting a new biomarker for schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Brain Imaging
Background:
- The striatum is a key brain region implicated in schizophrenia, exhibiting functional and structural abnormalities.
- Previous research has established functional connectivity between striatal and cortical regions in schizophrenia, but directional influences remain underexplored.
Purpose of the Study:
- To investigate the directed connectivity between the striatum and cortical regions in individuals with schizophrenia using resting-state fMRI.
- To identify specific patterns of information flow disruption within the striatum-default mode network (DMN) loop in schizophrenia.
Main Methods:
- Utilized resting-state functional magnetic resonance imaging (fMRI) to capture spontaneous brain activity.
- Applied Granger causality analysis to determine the directional influence between brain regions.
Main Results:
- Observed a significant impairment in the directed inhibitory influence from the striatum to the default mode network (DMN) in schizophrenia.
- Found a significant reduction in the reciprocal influence from the DMN back to the striatum.
Conclusions:
- The findings demonstrate a breakdown of the striatum-DMN loop in schizophrenia, characterized by disrupted directed connectivity.
- Abnormal directed influences between the striatum and DMN may serve as a potential biomarker for schizophrenia and indicate a therapeutic target.
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