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Clinical and genetic features of human metapneumovirus infection in children

Ji Young Park1, Ki Wook Yun1, Jae Woo Lim2

  • 1Departments of Pediatrics, Chung-Ang University College of Medicine, Seoul, Korea.

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 12, 2015
PubMed
Abstract

Insights

Human metapneumovirus (hMPV) infection in children presents with two distinct clinical patterns. This study identified differences in fever severity, inflammatory markers, and respiratory symptoms associated with hMPV genotypes.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Respiratory Medicine

Background:

  • Human metapneumovirus (hMPV) is a significant cause of respiratory illness in children.
  • Understanding hMPV's clinical spectrum is crucial for effective management.

Purpose of the Study:

  • To investigate the clinical presentations and genotype distribution of hMPV in Korean children.
  • To compare clinical features between high fever and low fever groups.

Main Methods:

  • Nasopharyngeal aspirates from children were tested for hMPV using RT-PCR (2011-2013).
  • hMPV genotypes were identified via PCR-restriction length polymorphism analysis of the fusion gene.
  • Patients were categorized into high fever (HF) and low fever (LF) groups based on fever characteristics.

Main Results:

  • Among 457 hMPV-positive samples, genotypes A2a, B1, and B2 were identified in 24.3%, 46.6%, and 29.1% respectively.
  • The HF group (n=80) showed significantly higher absolute neutrophil counts and C-reactive protein levels compared to the LF group (n=84).
  • Wheezing and dyspnea were more prevalent in the LF group, while genotype distribution was similar between groups.

Conclusions:

  • Two distinct clinical presentations of hMPV infection were observed in this cohort.
  • Clinical manifestations differ based on fever severity, suggesting varied host responses or viral interactions.
Keywords:
Koreachildrenfevergenotypehuman metapneumovirus

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