Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 5, 2026

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data
06:14

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data

Published on: April 18, 2019

7.0K

Concussion in Chronic Traumatic Encephalopathy.

Thor D Stein1, Victor E Alvarez, Ann C McKee

  • 1VA Boston Healthcare System, Boston, MA, 02130, USA, tdstein@bu.edu.

Current Pain and Headache Reports
|August 12, 2015
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subjective cognitive complaints and decline among aging individuals with prior repetitive head impact exposure.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

CTE has multiple pathologic variants that might relate to different clinical symptom presentation.

Acta neuropathologica·2026
Same author

Validity of the NINDS traumatic encephalopathy syndrome criteria for predicting chronic traumatic encephalopathy.

medRxiv : the preprint server for health sciences·2026
Same author

Associations Between Cumulative Head Trauma and Self-Reported Parkinsonism and Parkinson's Disease in Former Soccer Players.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Association of plasma glial fibrillary acidic protein and neurofilament light chain with retinal cell layer thickness: A cross-sectional study of ophthalmic surgical patients.

Journal of Alzheimer's disease : JAD·2026
Same author

Mitochondrial genetic variation across tissues of the human body.

Nucleic acids research·2026
Same journal

A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Epidural Regenerative Medicine Therapies in Managing Spinal Pain.

Current pain and headache reports·2026
Same journal

Artificial Intelligence in Neuropathic Pain: From Mechanisms to Neuromodulation and Regenerative Strategies.

Current pain and headache reports·2026
Same journal

Proposed Conditions for Pain Reprocessing Therapy Readiness: Beyond Phenotyping Neuroplastic Pain.

Current pain and headache reports·2026
Same journal

Treatment of Headache in Children and Adolescents with POTS.

Current pain and headache reports·2026
Same journal

Pediatric Headache in the Age of Social Media: A Topical Review.

Current pain and headache reports·2026
Same journal

Radiopharmaceuticals for the Treatment of Chronic Cancer Pain.

Current pain and headache reports·2026
See all related articles

Chronic traumatic encephalopathy (CTE) is a brain disease from repetitive head trauma. Years of exposure, not just concussions, drive CTE

Area of Science:

  • Neuroscience
  • Neuropathology
  • Sports Medicine

Background:

  • Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease linked to repetitive mild traumatic brain injury.
  • CTE presents with diverse clinical symptoms and distinct pathological changes, notably abnormal tau pathology in stress-concentrated brain regions.
  • Repetitive head trauma, common in contact sports, is the primary association, with a mean exposure of 15.4 years.

Purpose of the Study:

  • To review current knowledge on the exposure, clinical, and pathological associations of CTE.
  • To elucidate the relationship between head trauma characteristics and CTE development.
  • To explore the link between CTE and other neurodegenerative diseases like Alzheimer's.

Main Methods:

  • Review of published cases and data on CTE.

More Related Videos

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

1.1K
A Repetitive Concussive Head Injury Model in Mice
05:42

A Repetitive Concussive Head Injury Model in Mice

Published on: October 12, 2016

12.6K

Related Experiment Videos

Last Updated: Apr 5, 2026

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data
06:14

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data

Published on: April 18, 2019

7.0K
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

1.1K
A Repetitive Concussive Head Injury Model in Mice
05:42

A Repetitive Concussive Head Injury Model in Mice

Published on: October 12, 2016

12.6K
  • Analysis of exposure duration, concussion history, latency periods, and age of death.
  • Examination of pathological findings, including tau and amyloid-beta deposition.

    • Main Results:

    • The mean latency from head trauma to symptom onset is 14.5 years, with a mean age of death of 59.3 years.
    • While most CTE subjects report concussions, 16% do not, indicating subconcussive hits can contribute.
    • Longer exposure duration, rather than the number of concussions, correlated with worse tau pathology.

    Conclusions:

    • The chronic and repetitive nature of head trauma, regardless of concussive symptoms, is the key driver of CTE.
    • CTE is associated with accelerated amyloid-beta deposition, worsening disease severity.
    • Understanding these associations is crucial for diagnosing and potentially preventing CTE.