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High resolution whole brain diffusion imaging at 7T for the Human Connectome Project
A T Vu1, E Auerbach1, C Lenglet1
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA.
Neuroimage
|August 12, 2015
Summary
High-resolution diffusion MRI at 7T provides unprecedented detail for the Human Connectome Project. Optimized 7T acquisitions overcome field-specific challenges, yielding in-vivo data comparable to ex-vivo studies.
Area of Science:
- Neuroimaging
- Magnetic Resonance Imaging
Background:
- Human Connectome Project (HCP) relies on high-quality diffusion MRI (dMRI) for mapping brain connectivity.
- Ultrahigh fields (7T) offer higher signal-to-noise ratio (SNR) but present challenges like shorter relaxation times and B1 inhomogeneity.
Purpose of the Study:
- To present optimized 7T dMRI acquisition techniques for the HCP.
- To overcome limitations of dMRI at ultrahigh fields for in-vivo human brain imaging.
Main Methods:
- Developed and optimized multiband (MB)-accelerated 7T dMRI protocols.
- Conducted intensive pilot studies to address 7T specific challenges like SAR and B1 inhomogeneity.
- Acquired whole-brain, high-resolution, in-vivo dMRI data.
Main Results:
- Achieved high-quality, high-resolution whole-brain in-vivo dMRI data at 7T.
- Demonstrated spatial detail comparable to ex-vivo studies.
- Complemented existing high-quality 3T HCP data from the same subjects.
Conclusions:
- Recent advancements enable efficient, high-quality 7T dMRI for the HCP.
- Optimized 7T data significantly enhance in-vivo human connectome mapping.
- These datasets will be made publicly available.
