Related Experiment Video
Updated: Aug 9, 2026

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions
Published on: March 25, 2014
Isobolic determination of "ratio-linear" parameters in pharmacological stimulus-response models
1Department of Statistical Science, University College, London, England.
Abstract:
Two response models of fundamental importance in pharmacology are introduced, which are partly-specified functions of experimental variables, unknown parameters and random disturbances. An analysis is carried out of the extent of determination of the parameters from knowledge of isobol structure alone, with results that are more powerful than might have been expected. Moreover, such knowledge is exhaustive, unless untestable assumptions are admitted. The paper is not concerned with statistical methods for estimating the determined parameters.
Related Concept Videos
Dose-Response Relationship: Overview
Pharmacokinetic–Pharmacodynamic Relationship: Dose to Pharmacological Effect
Pharmacodynamic Models: Linear Concentration–Effect Model
Pharmacodynamic Models: Logarithmic Concentration–Effect Model
Pharmacodynamic Models: Additive and Proportional Drug Effect Model
Pharmacodynamic Models: Direct Effect Model and Indirect Response Model

