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[In vitro susceptibility of dermatophyte strains to imidazole derivatives]
M Bozkurt1, S Kuştimur, M A Gürer
1Gazi Universitesi, Tip Fakültesi, Dermatoloji Anabilim Dali, Oğretim Uyesi.
Abstract:
Recently, imidazole derivatives are being successfully used for the dermatomycoses. These drugs have the strongest antimycotic activity. 44 dermatophyte strains were isolated from our out-patient with dermatomycosis. Imidazole derivatives such as isoconazole, oxiconazole, bifonazole and tioconazole were studied their efficacy on these fungal agents in vitro. 4 imidazole derivatives were effective on all of the dermatophyte strains in less than or equal to 5 micrograms/ml concentration. Whereas, there were differences in Minimal Inhibition Concentration (MIC) and MIC50 values.
Insights
Imidazole antifungals show strong efficacy against dermatomycosis-causing fungi. Four derivatives effectively inhibited all 44 dermatophyte strains in vitro at low concentrations, demonstrating their potential for treating fungal skin infections.
Area of Science:
- Mycology
- Dermatology
- Pharmacology
Background:
- Dermatomycoses are common superficial fungal infections.
- Imidazole derivatives are recognized for potent antimycotic activity.
- Emerging resistance necessitates evaluating existing antifungal efficacy.
Purpose of the Study:
- To assess the in vitro efficacy of four imidazole derivatives against clinical dermatophyte isolates.
- To determine the minimum inhibitory concentrations (MIC) and MIC50 values for selected imidazoles.
Main Methods:
- Isolation of 44 dermatophyte strains from outpatients diagnosed with dermatomycosis.
- In vitro susceptibility testing of isoconazole, oxiconazole, bifonazole, and tioconazole.
- Determination of Minimum Inhibition Concentration (MIC) and MIC50 values.
Main Results:
- All four imidazole derivatives demonstrated efficacy against all tested dermatophyte strains.
- Effective concentrations were found to be less than or equal to 5 micrograms/ml.
- Variations in MIC and MIC50 values were observed among the imidazole derivatives tested.
Conclusions:
- The studied imidazole derivatives exhibit broad-spectrum activity against common dermatophytes.
- These agents are effective at low concentrations, supporting their clinical use in dermatomycosis.
- Further investigation into MIC variations may guide optimal therapeutic selection.