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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Bronchiolitis obliterans in children--a report of six cases

A H Omar, A Manan

    The Medical Journal of Malaysia
    |September 1, 1989
    PubMed

    Insights

    Severe bronchiolitis in children can lead to persistent respiratory symptoms like breathlessness and cough. However, long-term outcomes are generally satisfactory, with most children showing improvement over time.

    Area of Science:

    • Pediatrics
    • Pulmonology
    • Infectious Diseases

    Background:

    • Severe acute bronchiolitis in infancy and early childhood can result in persistent respiratory sequelae.
    • Children may experience symptoms such as breathlessness, cough, and wheeze that are resistant to standard bronchodilator therapy.

    Purpose of the Study:

    • To describe the clinical features, etiology, and long-term prognosis of children with persistent respiratory symptoms following severe acute bronchiolitis.

    Main Methods:

    • Case series describing six children with persistent symptoms after severe acute bronchiolitis.
    • Clinical examination, radiological assessment, and in one case, lung biopsy were utilized.
    • Etiological investigations included testing for measles and adenovirus.

    Main Results:

    • Persistent symptoms included breathlessness, cough, wheeze, chest hyperinflation, crepitations, and rhonchi.
    • Failure to thrive was noted in most patients.
    • Measles and adenovirus were identified as potential etiological agents in some cases; others remained unknown.

    Conclusions:

    • The clinical presentation and course were consistent with bronchiolitis obliterans.
    • Despite prolonged illness, the long-term prognosis was favorable, with significant improvement in respiratory signs, growth, and general health observed over four to eight years.

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