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Canine model of crush syndrome established by a digital crush injury device platform
Jie Song1, Hui Ding2, Hao-Jun Fan2
1Tianjin Medical University Tianjin 300162, P. R. China ; Key Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces Tianjin 300162, P. R. China ; Department of Nephrology, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces Tianjin 300162, P. R. China.
Objective:
To establish a canine model of crush syndrome (CS).
Methods:
A total of 16 healthy adult female Beagle dogs were randomly divided into the control group (n=8) and the experimental group (n=8). The crush injury was created in the left hind leg of each dog in the experimental group.
Results:
The biochemical indexes in the experimental group changed significantly compared to the values before extrusion. And they were also significantly different from the values of the control group. The glomerular capillary dilation, renal tubular epithelial cell degeneration, and renal interstitial lymphocytic infiltration were found in the kidneys.
Conclusion:
The canine CS model established by the digital crush injury device platform was successful according with the diagnosis of CS. It is good for the investigation of the CS mechanism and treatment using this model.
