[Experimental study on the effect of various types of peritonitis and elevation of intra-abdominal pressure on...

The experimental studies were conducted in order to elucidate the effect of intra-abdominal chemical and bacterial inflammation and elevation of intraabdominal pressure on endotoxin (Et) absorption from the peritoneum. Sixty three adult mongrel dogs were subjected to this study by producing models by intra-abdominally administering only Et (0.5mg/kg) [Et only group], by intra-abdominally administering a same dose of Et after inducing peritonitis by bile, stool and acid [Peritonitis group], and by intra-abdominally administering a same dose of Et after elevating intraabdominal pressure [Elevated intraabdominal pressure group]. In comparison with the group in which only Et was intra-abdominally administered, Et absorption of the Peritonitis group was significantly inhibited and the response of the animals was minimal. It was suggested that peritonitis per se had a host defensive function with regard only to Et absorption. However, in the elevated intra-abdominal pressure group, Et absorption from the peritoneal cavity was significantly increased to bring rise to aggravation of the circulatory system such as decrease in not only blood pressure but also in its antecedent cardiac output and hepatic blood flow, which aggravated the severity of the disease.