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Related Experiment Videos

Paternal behavioral mutagenesis.

E L Abel1

  • 1Fetal Alcohol Research Center, Wayne State University, Detroit, Michigan.

Neurotoxicology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Paternal exposure to cocaine hydrochloride or alcohol in rats led to significant behavioral changes in offspring. Cocaine caused hyperactivity, while alcohol resulted in hypoactivity, demonstrating transgenerational effects of substance use.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Reproductive Science

Background:

  • Paternal substance use is a growing public health concern.
  • Understanding the transgenerational impact of paternal exposure to drugs and alcohol is crucial for developmental health.
  • Long Evans rats are a well-established model for studying behavioral teratology.

Purpose of the Study:

  • To investigate the effects of paternal cocaine hydrochloride administration on offspring behavior.
  • To examine the effects of paternal alcohol consumption on offspring behavior.
  • To determine if paternal substance exposure induces lasting behavioral changes in offspring.

Main Methods:

  • Male Long Evans rats were administered daily subcutaneous injections of cocaine hydrochloride (0-30 mg/kg) for at least 72 days.

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  • Male Long Evans rats consumed alcohol (0%, 17.5%, or 35% ethanol-derived calories) for 8-9 weeks.
  • In both studies, males were bred with untreated females, and offspring were assessed for behavioral changes.
  • Pair-feeding was employed to control for nutritional effects.

    • Main Results:

    • Paternal cocaine hydrochloride administration did not impact litter size, birth weight, or weaning weight but resulted in offspring hyperactivity.
    • Paternal alcohol consumption did not affect offspring birth weight or weaning weight but led to hypoactivity.
    • Mice sired by alcohol-consuming males also exhibited hypoactivity.

    Conclusions:

    • Paternal exposure to cocaine hydrochloride and alcohol can induce distinct behavioral alterations in offspring.
    • These findings suggest that paternal substance use may have transgenerational effects on neurodevelopment and behavior.
    • Further research is warranted to elucidate the mechanisms underlying these observed behavioral changes.