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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Related Experiment Video

Updated: Apr 5, 2026

Small Bowel Transplantation In Mice
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Pediatric small bowel transplantation.

Esther Ramos Boluda1

  • 1Pediatric Gastroenterology Intestinal Rehabilitation Unit, University Pediatric Hospital La Paz, Paseo de la Castellana, Madrid, Spain.

Current Opinion in Organ Transplantation
|August 12, 2015
PubMed
Summary
This summary is machine-generated.

Intestinal transplantation survival rates are improving due to advanced immunosuppression and early referral. Key challenges remain in managing rejection and preventing complications like GVHD for better long-term outcomes.

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Last Updated: Apr 5, 2026

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Area of Science:

  • Gastroenterology
  • Transplantation Medicine
  • Immunology

Background:

  • Intestine transplantation is now feasible due to improved immunosuppressive drugs.
  • Early referral to specialized centers is critical for patient prognosis.
  • Significant challenges persist, including chronic rejection and early detection of acute rejection.

Purpose of the Study:

  • To review the current state of intestinal transplantation.
  • To highlight advancements in immunosuppression and their impact.
  • To identify ongoing challenges and future directions in the field.

Main Methods:

  • Review of recent literature on intestinal transplantation.
  • Analysis of outcomes associated with new immunosuppressive agents (tacrolimus, mTOR).
  • Evaluation of the role of induction therapy and graft composition.

Main Results:

  • Tacrolimus, mTOR inhibitors, and induction therapy have improved graft and patient survival.
  • Liver inclusion in the graft shows a protective effect.
  • Antibody-mediated rejection is an increasing concern, alongside infection, PTLD, and GVHD.

Conclusions:

  • Intestinal transplantation is a viable option for intestinal failure unresponsive to parenteral nutrition.
  • Balancing immunosuppression to prevent rejection and complications (PTLD, GVHD) is a critical ongoing challenge.
  • Current intestinal transplant survival rates are comparable to other solid organ transplants.