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THE ASSOCIATION BETWEEN PRE-PREGNANCY OBESITY AND WEIGHT GAIN IN PREGNANCY, WITH GROWTH DEVIATIONS IN NEWBORNS
Dennis Camacho-Buenrostro1, J Jesús Pérez-Molina2, Edgar M Vásquez-Garibay3
1Instituto de Nutrición Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, (Jalisco).. jesusperezmolina@gmail.com.
Insights
Maternal pre-pregnancy obesity and excessive weight gain during pregnancy are significant predictors of newborns being large for gestational age (LGA). This study highlights risks for infants born to mothers with obesity, emphasizing the need for monitoring. Keywords: maternal obesity, pregnancy weight gain, large for gestational age.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Medicine
- Maternal-Fetal Health
Background:
- Pregnancy obesity is linked to increased maternal and fetal morbidity.
- Understanding the impact of maternal pre-pregnancy weight on infant growth is crucial for perinatal care.
Purpose of the Study:
- To quantify the association between pre-pregnancy obesity and infant growth deviations.
- To identify predictors of large for gestational age (LGA) and small for gestational age (SGA) newborns.
Main Methods:
- A case-control study was conducted involving 280 mother-child dyads.
- Logistic regression analysis assessed the relationship between pre-pregnancy obesity and infant size (LGA/SGA).
- Gynecoobstetric and socioeconomic data were collected and analyzed.
Main Results:
- Pre-pregnancy obesity was significantly associated with growth deviations (OR 2.65).
- Elevated weight gain during pregnancy (OR 1.98) and maternal disease (OR 2.62) were also linked to deviations.
- Multivariate analysis confirmed pre-pregnancy obesity and high gestational weight gain as predictors of LGA.
Conclusions:
- Pre-pregnancy obesity and excessive gestational weight gain are key predictors of LGA in newborns.
- Findings are particularly relevant for young women with limited economic resources.
- These factors underscore the importance of weight management during pregnancy.
Introduction:
obesity in pregnancy has been associated with increased morbidity for the mother and fetus.
Objective:
to quantify the association between obesity in pregnancy with growth deviations of their newborn infants.
Methods:
a study of non-matched cases and controls was performed based on the Nuevo Civil Hospital of Guadalajara "Dr. Juan I Menchaca" 2012-2013. The dependent variables were the newborn being either large (LGA) or small for gestational age (SGA), and the independent variable was pre-pregnancy obesity. Gynecoobstetric and socioeconomic data were collected. The association between the dependent and independent variables was assessed with logistic regression.
Results:
one-hundred and forty-three mother-child dyads were studied with growth deviations of their newborn infants, and 137 mother-child dyads without growth deviations were studied. The age of the patients was 24.7 ± 6.3 vs. 24.0 ± 6.0 years, and the gestational age was 38 ± 1.2 vs. 38 ± 1.5. Factors associated with growth deviations were pre-pregnancy obesity (OR 2.65, 95% CI 1.29- 5.44), elevated weight gain during pregnancy (OR 1.98, 95% CI 1.04-3.76) and disease during pregnancy (OR 2.62, 95% CI 1.05-6.76). A multivariate model with the dependent variable LGA and associated covariates showed that pre-pregnancy obesity and high gestational weight gain were predictors of LGA (OR 2.43, 95% CI 1.10-5.40) and (OR 3.31, 95% CI 1.83-5.96).
Conclusions:
in a population of young women with scarce economic resources, pre-pregnancy obesity and high weight gain during pregnancy were predictors of LGA.
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