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Updated: Apr 5, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
A combined vascular surgical and clinical genetics approach to diffuse aneurysmal disease
K A Jones1, A M T L Choong, N Canham2
1Outer London North West Vascular Unit, Northwick Park Hospital, London North West Healthcare NHS Trust , UK.
Abstract:
We report two patients who presented with extensive aneurysmal disease, in association with minimal external physical signs. Patient 1 remained genetically undiagnosed despite multiple structural, biochemical and genetic investigations. He made a good recovery following surgery for popliteal and left axillary artery aneurysms. Patient 2 was diagnosed with vascular type Ehlers-Danlos syndrome, associated with a high degree of tissue and blood vessel fragility, and is being managed conservatively. Early multidisciplinary assessment of such patients facilitates accurate diagnosis and management.
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