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Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells
Yung-Tin Pan1, Cartney E Smith1, Kam Sang Kwok1
1University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering, 206 Roger Adams Lab, Box C-3, MC-712, 600 South Methews Avenue, Urbana, IL 61801 (USA).
Abstract:
Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functionalized Pd nanosheets exhibited a much higher cytotoxicity, showing more than 80% cell death at 100 ppm than the negatively charged 3-mercaptopropionic acid (MPA) functionalized ones which caused 30% cell death. The results show through surface functionalization Pd nanosheets can be modified to interact differently with HepG2 cancerous cells, resulting in varied cytotoxicity.
