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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

Updated: Apr 5, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method.

Tuong Ngoc-Gia Nguyen1, Phuong Ha-Lien Tran2,3, Toi Van Vo1

  • 1Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Vietnam.

Pharmaceutical Research
|August 13, 2015
PubMed
Summary

This study developed a novel sustained release solid dispersion using a swellable polymer, hydroxypropyl methylcellulose 4000 (HPMC 4000), and polyethylene glycol 6000 (PEG 6000) via a melting method.

Keywords:
poorly water-soluble drugsolid dispersionsustained releaseswellable polymer

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Sustained drug release is crucial for therapeutic efficacy and patient compliance.
  • Traditional solid dispersions often face challenges in achieving controlled release profiles.
  • Developing novel formulations for enhanced drug delivery remains a key area in pharmaceutical research.

Purpose of the Study:

  • To design and develop a sustained release solid dispersion using a swellable polymer via a melting method.
  • To investigate the potential of hydroxypropyl methylcellulose 4000 (HPMC 4000) as a swellable polymer in solid dispersion formulations.
  • To enhance both drug dissolution rate and achieve sustained drug release.

Main Methods:

  • Utilized a melting method for solid dispersion preparation.
  • Incorporated polyethylene glycol 6000 (PEG 6000) as a carrier and hydroxypropyl methylcellulose 4000 (HPMC 4000) as a swellable polymer.
  • Leveraged the swelling capability of HPMC 4000 in conjunction with PEG 6000.

Main Results:

  • Polyethylene glycol 6000 (PEG 6000) facilitated the swelling of HPMC 4000, acting as a releasing stimulant carrier.
  • Hydroxypropyl methylcellulose 4000 (HPMC 4000) functioned as a rate-controlling agent, enabling sustained release.
  • The solid dispersion formulation enhanced drug dissolution by altering the drug's crystalline structure to a more amorphous form and establishing molecular interactions.

Conclusions:

  • The developed technique is effective for designing sustained release solid dispersions.
  • The combination of PEG 6000 and HPMC 4000 offers a promising approach for controlled drug delivery.
  • This method presents significant advantages for pharmaceutical formulation development.