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Developments and advances concerning the hyperpolarisation technique SABRE.

¹School of Science and the Environment, Division of Chemistry and Environmental Science, Manchester Metropolitan University, John Dalton Building, Chester St., Manchester, M1 5GD, UK.

Magnetic Resonance in Chemistry : MRC

|August 13, 2015

Summary

Signal Amplification By Reversible Exchange (SABRE) enhances NMR and MRI sensitivity using parahydrogen. This technique facilitates polarization transfer to analytes, enabling novel MRI contrast agents and fundamental mechanism studies.

Keywords:

13C 1H 31P NMR SABRE hyperpolarisation parahydrogen

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Area of Science:

Hyperpolarization techniques in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI).

Background:

NMR and MRI face inherent sensitivity limitations.
Parahydrogen, a molecule with a nuclear singlet state, is a polarization source.
Metal complexes are crucial for facilitating polarization transfer from parahydrogen to analytes.

Purpose of the Study:

To investigate the potential of Signal Amplification By Reversible Exchange (SABRE) for enhancing NMR and MRI sensitivity.
To explore the use of SABRE-derived hyperpolarized molecules as MRI contrast agents.
To understand the fundamental mechanisms of polarization transfer in SABRE.

Main Methods:

Utilizing parahydrogen as a polarization source.
Employing metal complexes to facilitate polarization transfer.
Investigating polarization transfer through J-coupled networks.
Implementing SABRE at varying magnetic field strengths (low and high).

Main Results:

Achieved significant signal amplification for analyte molecules.
Demonstrated the feasibility of using SABRE for MRI contrast enhancement.
Provided insights into the chemical structure requirements for the metal complex.
Discussed physical constraints influencing the polarization transfer process.

Conclusions:

SABRE effectively overcomes sensitivity issues in NMR and MRI.
The technique shows promise for developing novel MRI contrast agents.
Further understanding of the polarization transfer mechanism is crucial for optimization.
Successful implementation across different magnetic field strengths highlights SABRE's versatility.