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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
Published on: March 7, 2017
A clinicopathologic study of diencephalic pediatric low-grade gliomas with BRAF V600 mutation
Cheng-Ying Ho1,2,3, Bret C Mobley4, Heather Gordish-Dressman5,6
1Division of Pathology, Children's National Medical Center, 111 Michigan Ave, NW, Washington DC, 20010, USA. cho@childrensnational.org.
Abstract:
Among brain tumors, the BRAF (V600E) mutation is frequently associated with pleomorphic xanthoastrocytomas (PXAs) and gangliogliomas (GGs). This oncogenic mutation is also detected in ~5 % of other pediatric low-grade gliomas (LGGs) including pilocytic astrocytomas (PAs) and diffuse astrocytomas. In the current multi-institutional study of 56 non-PXA/non-GG diencephalic pediatric LGGs, the BRAF (V600) mutation rate is 36 %. V600-mutant tumors demonstrate a predilection for infants and young children (
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